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Denosurel 120mg Injection
PRODUCT DETAILS
About Denosurel 120mg Injection
DENOSUMAB belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. DENOSUMAB is also used to treat bone loss due to reduced testosterone levels caused by surgery, due to the treatment with medicines such as glucocorticoids and in patients with prostate cancer. DENOSUMAB may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumours of the bone, and to treat high calcium levels caused due to cancer.
DENOSUMAB contains ‘denosumab’, which works by blocking a receptor in the body which causes bone loss, thereby treating bone loss. DENOSUMAB treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the tumour growth. DENOSUMAB helps treat high calcium levels by decreasing bone breakdown as a breakdown of the bones releases calcium. DENOSUMAB makes the bones stronger and less likely to break.
DENOSUMAB will be administered by a healthcare professional; do not self-administer. You are advised to take DENOSUMAB for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. You are advised to talk to your doctor if you experience these side effects persistently.
DENOSUMAB might cause osteonecrosis of the jaw; therefore, whilst on treatment with DENOSUMAB, maintain good dental hygiene and receive regular dental check-ups. Avoid taking DENOSUMAB if you are pregnant. Consult your doctor before taking DENOSUMAB if you are breastfeeding. DENOSUMAB is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.
Uses of Denosurel 120mg Injection
Osteoporosis, bone loss, giant cell tumor of the bone, high calcium levels.
Medicinal Benefits of Denosurel 120mg Injection
DENOSUMAB belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. DENOSUMAB is also used to treat bone loss due to reduced hormone levels caused by surgery or due to treatment with medicines in patients with prostate cancer. It is also used to treat bone loss occurring due to long-term treatment with glucocorticoids in patients who are at an increased risk of fractures. DENOSUMAB may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumours of the bone, and to treat high calcium levels caused due to cancer. DENOSUMAB binds to a protein on the RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. Thereby decreasing bone breakdown, increasing bone density, and strengthening the bone. DENOSUMAB treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the tumour growth. DENOSUMAB helps treat high calcium levels by decreasing bone breakdown as the breakdown of the bones releases calcium. DENOSUMAB makes the bones stronger and less likely to break.
Directions for Use
DENOSUMAB will be administered subcutaneously in the upper arm, abdomen, or upper thigh by a healthcare professional; do not self-administer. Based on your medical condition, your doctor will decide how long you need to take DENOSUMAB.
Side Effects of Denosurel 120mg Injection
- Bone/joint/muscle pain
- Pain in extremities (arm/leg pain)
- Abdominal discomfort
- Constipation
- Painful/frequent urination
- Upper respiratory tract infection
- Rash
- Eczema
- Hair loss
Similar Drugs
For informational purposes only. Consult a doctor before taking any medicines.
In-Depth Precautions and Warning
Drug Warnings
Do not take DENOSUMAB if you are allergic to DENOSUMAB or any of its contents; if you have hypocalcemia (low levels of calcium in the blood). Inform your doctor if you have low levels of calcium, kidney dysfunction, liver problems, poor dental health, gum problems, weak immune system, hypoparathyroidism (decreased function of the parathyroid gland), malabsorption, latex allergy, undergone thyroid surgery, planned dental procedure, if you are taking glucocorticoids, or cannot take calcium and vitamin D supplements. Avoid taking DENOSUMAB if you are pregnant. Consult your doctor before taking DENOSUMAB if you are breastfeeding. DENOSUMAB is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.
Drug Interactions
Drug-Drug Interaction:
DENOSUMAB may have interaction with kinase inhibitors (palbociclib).
Drug-Disease Interaction:
DENOSUMAB may have interactions with hypocalcemia (low levels of calcium in the blood) and immunosuppression.
Safety Advice
ALCOHOL
It is not known if alcohol interacts with DENOSUMAB, so please consult a doctor.
PREGNANCY
DENOSUMAB is not recommended during pregnancy as it might cause fetal harm. If you are a woman of child-bearing potential, use effective contraception during the treatment with DENOSUMAB and for 5 months after discontinuation. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.
BREAST FEEDING
Consult your doctor if you are breastfeeding; your doctor will decide if breastfeeding mothers can take DENOSUMAB or not.
DRIVING
DENOSUMAB generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.
LIVER
Please consult your doctor if you have a liver impairment or any concerns regarding this.
KIDNEY
Please consult your doctor if you have kidney impairment or any concerns regarding this.