PRODUCT DETAILS

About Kombiglyze XR 5mg/500mg Tablet

SAXAGLIPTIN+METFORMIN belongs to a group of medicines known as'antidiabetics', used in the treatment of type 2 diabetes in adults. SAXAGLIPTIN+METFORMIN is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control their blood sugar levels. It is the first-line therapy for patients with type 2 diabetes that restores the body's response to insulin. Insulin is the hormone that controls sugar levels in your blood. People with type 2 diabetes either do not produce enough insulin or the insulin produced is unable to perform its function in the body (insulin resistance). Middle-aged or older individuals are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes.

SAXAGLIPTIN+METFORMIN contains two medications namely: Saxagliptin and Metformin. Saxagliptin work by blocking the action of DPP-4- dipeptidyl peptidase-4  (an enzyme that destroys the hormone ‘Incretin’). The enzyme ‘Incretins’ help to produce more insulin only when required and reduce blood sugar level produced by the liver when not needed. On the other hand, Metformin, which is a 'biguanide', acts by lowering the liver's glucose production, delaying glucose absorption from the intestines, and increasing the body's response to insulin. In a nutshell, the two medicines together prevent the blood glucose levels from rising to very high levels, thus keeping your Diabetes under control.

Uses of Kombiglyze XR 5mg/500mg Tablet

Type 2 diabetes (non-insulin-dependent diabetes).

Medicinal Benefits of Kombiglyze XR 5mg/500mg Tablet

SAXAGLIPTIN+METFORMIN contains two medications namely: Saxagliptin and Metformin. SAXAGLIPTIN+METFORMIN act together to keep your blood sugar levels under check. The strict control of blood sugars is essential to mention the many disabling side effects of Diabetes. SAXAGLIPTIN+METFORMIN shows optimum effects when taken along with healthy lifestyle changes like weight loss, regular exercise, a healthy diet, etc.  SAXAGLIPTIN+METFORMIN should not be used in patients with type 1 diabetes and for the treatment of diabetic ketoacidosis. Thus, SAXAGLIPTIN+METFORMIN plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), and nerve damage (neuropathy), diabetic foot ulcer, and delayed wound healing.

Directions for Use

Swallow the tablet whole with a glass of water at the start of a meal or slightly before. Space the doses evenly during the day, at least 4 hours apart. Do not chew or crush it.

Side Effects of Kombiglyze XR 5mg/500mg Tablet

• Dizziness
• Sweating
• Palpitations
• hunger pangs
• Dry mouth and skin
• Hypoglycaemia (low blood glucose level)

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug-Drug Interaction:

SAXAGLIPTIN+METFORMIN interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-HIV drugs (dolutegravir), ethanol, saliva reducing drugs (glycopyrrolate), iodinated X-ray contrast agents, anti-epileptic drugs (topiramate, lamotrigine), heart-related chest medicine (ranolazine). Other drug interactions can contribute to an increased low blood sugar including sex hormones (androgens), anti-oxidant (alpha-lipoic acid), painkillers (aspirin), anti TB drugs (prothionamide), growth hormones (pegvisomant), and other antidiabetic medicines.

Safety Advice

ALCOHOL

SAXAGLIPTIN+METFORMIN is not advised to be taken with alcohol as it causes bizarre interactions. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink.

 

DRIVING

Caution is to be taken. If a patient feels dizzy while taking SAXAGLIPTIN+METFORMIN, do not drive or use any tools or machines. Hypoglycaemia may affect your ability to drive and use machines or work with a safe foothold and there is a risk of hypoglycaemia after taking this medicine in combination with other medicines known to cause hypoglycaemia such as insulin and sulphonylureas.

 

LIVER

Caution is to be taken in liver patients.

KIDNEY

Caution is to be taken in kidney patients.