PRODUCT DETAILS

About Mesolit Injection

MESNA belongs to a class of medication known as 'cytoprotectant' primarily used to prevent bleeding into the urine due to the effect of anticancer agents like 'ifosfamide' and 'cyclophosphamide'. This reduces the risk of inflammation and bleeding in the bladder due to other anti-cancer medication. Our body breaks down the anticancer agent (ifosfamide) to form a chemical (acrolein) that can harm and irritate the bladder. MESNA works by making this natural chemical less harmful or toxic. However, MESNA does not change ifosfamide's anti-cancer effects.

Uses of Mesolit Injection

Bladder bleeding due to chemotherapy (hemorrhagic cystitis)

Medicinal Benefits of Mesolit Injection

MESNA belongs to a class of medication known as 'chemoprotectant' primarily used to prevent bleeding into the urine by a particular anticancer medicine known as ifosfamide (ifosfamide-induced hemorrhagic cystitis). It also reduces the risk of inflammation and bleeding in the bladder, receiving any anti-cancer medication. It contains Mesna, which works by reacting chemically with the urotoxic ifosfamide (anti-cancer medicines) metabolites, resulting in their detoxification. In addition to this, it also binds to other urotoxic metabolites and inhibits their effects on the bladder.

Directions for Use

Take the tablet of MESNA with or without food or as directed by your physician. Swallow the whole tablet with a glass of water. Do not crush, chew, or break it. Injection or infusion form should be taken under medical supervision.

Side Effects of Mesolit Injection

• Nausea
• Headache
• Flushing (sense of warmth in the face, ears, neck and trunk)
• Lethargy
• Rash
• Diarrhea
• Lightheadedness
• Abdominal pain
• Flu-like symptoms
• Fever

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take MESNA if you are allergic to MESNA or any of its ingredients. MESNA injection or infusion should be done under the supervision of a doctor only. An effective birth control measure should be taken to avoid pregnancy in women with a mother bearing age. Also, maintain a gap of a minimum of 6 months in the last dose of MESNA taken and your next pregnancy. Regular urine and blood test should be done while taking $nma to monitor your CBC (blood cell count). MESNA is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. It is important to drink at least 1 liter of fluid daily while taking MESNA. MESNA is known to cause blurry vision and dizziness, so do not drive or operate machinery.

Drug Interactions

Drug-Drug Interaction:

MESNA is known to interact in patients with an autoimmune disorder like rheumatoid arthritis (pain and inflammation in the joints), systemic lupus erythematosus (a severe form of lupus in which pain and fatigue occur in joints), or nephritis (a type of kidney problem).

Drug-Disease Interaction:

 MESNA is known to interact with anticoagulants (anisindione, dicumarol, warfarin).

Safety Advice

ALCOHOL

• MESNA if taken along with alcohol may increase drowsiness, so it should not be taken along with alcohol.

PREGNANCY

• MESNA is a category B pregnancy medicines. It has not shown any harm to the baby but should only be taken if a doctor prescribes you.

BREAST FEEDING

• MESNA should not be taken if you are breastfeeding as it is known to pass through the breast milk and harm the baby. Maintain a gap of 1 week after stopping MESNA before breastfeeding.

DRIVING

• MESNA is known to cause blurred vision and drowsiness. So, do not drive or operate machinery which requires concentration.

LIVER

• Let your doctor know if you have any history of liver diseases before using MESNA. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

KIDNEY

• Let your doctor know if you have any history of kidney diseases before using MESNA. Your doctor will weigh the benefits and any potential risks before prescribing it to you.