PRODUCT DETAILS

About Twoprox 500mg Tablet ER

DIVALPROEX belongs to a class of drugs called anti-epileptics also known as anticonvulsant medications. It is used to treat neurological conditions. It is used for the treatment of manic episodes in bipolar disorder, complex partial seizures, simple and complex absence seizures, and other types of seizures that include absence seizures. It is used as prophylaxis for migraines. Bipolar disorder is a mental health condition that affects your moods, which can swing from one extreme to another. It used to be known as manic depression. A seizure is a sudden, uncontrolled electrical disturbance in the brain. It can cause changes in your behavior, movements or feelings, and in levels of consciousness.

DIVALPROEX is available for oral use in the form of tablets. Swallow the tablets as a whole. Do not crush, chew, or break the tablets. The dose and duration of the treatment are given by your doctor. The doctor may increase or decrease the dose gradually depending on your health condition. It is given as monotherapy or adjunctive therapy to treat seizures. DIVALPROEX works by reducing or preventing manic episodes by increasing the amount of a chemical called gamma-aminobutyric acid (GABA) in the brain. GABA blocks transmission across nerves in the brain and has a calming effect.

DIVALPROEX causes significant hepatotoxicity, so it should be used with extreme caution in patients with liver failure. It can cause fetal defects, so it should be used with caution in women of childbearing potential. Your doctor may advise you to take effective contraception while using this medication. Some patients may develop pancreatitis after using DIVALPROEX. In such cases, the doctor may ask you to discontinue the medication.

Common side-effects of DIVALPROEX are abdominal pain, hair loss, blurred vision, double vision, loss of memory, loss of appetite, tiredness, back pain, constipation, depression, diarrhea, dizziness, indigestion, shortness of breath, fever, flu syndrome, headache, nausea, vomiting, impaired cognition, and weight gain. Some patients may also develop suicidal thoughts after using this medication. Contact your doctor immediately if any of these side effects persist or worsen.

Do not take DIVALPROEX if you are allergic to Divalproex or any other ingredients present in it. Before taking DIVALPROEX, tell your doctor if you are using any other anticonvulsants, other prescription or non-prescription drugs, or any dietary supplements. Inform your doctor if you are previously diagnosed with any brain disorder, depression, or pancreatitis. Do not use it if you have a medical history of liver diseases, urea cycle disorder (metabolic disorder), or Alpers-Huttenlocher syndrome (mitochondrial disorder). Tell your doctor DIVALPROEX if you are pregnant, planning to become pregnant, or breastfeeding.

Uses of Twoprox 500mg Tablet ER

Bipolar disorder, complex partial seizures, absence seizures, migraine headache

Medicinal Benefits of Twoprox 500mg Tablet ER

DIVALPROEX belongs to the class of anticonvulsant drugs. It is used in the treatment of complex partial seizures and complex absence seizures as monotherapy or adjunctive therapy, manic episodes of bipolar disorder, and prevention of migraine headaches. In general, these neurological conditions occur due to abnormal electrical activity in the brain. DIVALPROEX can block the nerve signals across the neuron membrane and reduce the abnormal activity, eventually improving the symptoms.

Directions for Use

Take the dose as prescribed by your doctor. Swallow the tablet as a whole with a glass of water. Do not crush, chew, or break the tablet. Do not increase or decrease the dose without a doctor's advice. If you miss a dose, skip it and take the next dose as usual at the fixed time.

Side Effects of Twoprox 500mg Tablet ER

Like any other medicines, DIVALPROEX can also cause side effects such as abdominal pain, asthenia (lack of energy), dizziness, drowsiness, nausea, vomiting, and thrombocytopenia (decreased platelet count), blurred vision, and anorexia (loss of appetite). Other side effects are an abnormality in thinking, memory loss, alopecia (hair loss), impaired balance, nystagmus disorder (involuntary eye movement), tremor, weight loss, fever, and skin rash. You may also gain weight while using DIVALPROEX.

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take DIVALPROEX if you are allergic to DIVALPROEX or any other ingredients present in it. Before taking DIVALPROEX, tell your doctor if you are using any other anticonvulsants, salicylates, antidepressants, anticoagulants, oral contraceptives, or any dietary supplements. Inform your doctor if you are previously diagnosed with any brain disorder, depression, pancreatitis, and thrombocytopenia. Do not use it if you have a medical history of liver diseases, urea cycle disorder (metabolic disorder), or Alpers-Huttenlocher syndrome (mitochondrial disorder). Inform your doctor immediately if you develop any suicidal thoughts or your convulsions worsen while using DIVALPROEX. Tell your doctor DIVALPROEX if you are pregnant, planning to become pregnant, or breastfeeding.

Drug Interactions

Drug-Drug Interaction:

 DIVALPROEX may interact with other anticonvulsants (phenobarbital, primidone, phenytoin, carbamazepine, ethosuximide, lamotrigine, topiramate, and felbamate), salicylate (aspirin), antidepressants (diazepam and amitryptiline), antiretroviral drug (zidovudine), antibiotics (rifampicin), an anticoagulant drug (warfarin).  

Drug-Disease Interaction:

DIVALPROEX should be used with caution in patients with liver diseases, depression, urea cycle disorder, and Alpers-Huttenlocher syndrome.

Safety Advice

ALCOHOL

DIVALPROEX may interact with alcohol and increase the risk of side effects.

PREGNANCY

DIVALPROEX is toxic to the fetus. So, it is used with extreme caution in pregnant women and women with childbearing potential.

BREAST FEEDING

DIVALPROEX should be with caution in breastfeeding mothers.

DRIVING

DIVALPROEX can cause drowsiness. So, it is recommended to avoid driving or operating heavy machinery after taking DIVALPROEX.

LIVER

DIVALPROEX is hepatotoxic and should be used with caution in patients with severe liver impairment. Dose adjustments may be necessary.

KIDNEY

DIVALPROEX should be used in patients with kidney problems only when prescribed by a doctor.